I stayed right off Piazza Navona in Rome and it was great. Walking distance (*assuming you're cool with walking 10+km per day) to all the touristy shit, restaurants, etc. It's right in the middle between Vatican City and the Colosseum. Trastevere would also be a good choice just across the river.Any suggestions for neighborhoods to stay in Rome and Florence? Didn't love the areas I stayed in a few years ago, so open to ideas!